On immunosurveillance in human cancer.
نویسنده
چکیده
The extraordinarily high incidence of cancers of many different varieties--carcinomas and lymphomas--in organ-transplant patients being maintained for long periods of time with immunosuppressive drugs is briefly reviewed. The role of immunosurveillance as a primary defense mechanism against cancer in human beings is consistent with these observations and is in need of further investigation. Conceivably, this mechanism may play a somewhat different role in humans from what has been observed in most experimental animal models.
منابع مشابه
The immunobiology of cancer immunosurveillance and immunoediting.
The last fifteen years have seen a reemergence of interest in cancer immunosurveillance and a broadening of this concept into one termed cancer immunoediting. The latter, supported by strong experimental data derived from murine tumor models and provocative correlative data obtained by studying human cancer, holds that the immune system not only protects the host against development of primary ...
متن کاملThe emerging role of immunosurveillance in dictating metastatic spread in breast cancer.
It is now well known that the immune system can recognize transformed cells and control the initiation and growth of some cancers, a process termed tumor immunosurveillance. Key regulators of this process have been described in the primary tumor setting, where the balance of protumor and antitumor responses dictates tumor initiation and progression. Accumulating evidence suggests that immunosur...
متن کاملHuman leukocyte antigen-G and cancer immunoediting.
Immunosurveillance is an extrinsic mechanism of cancer suppression that eliminates nascent tumors. However, the selection imposed by immunosurveillance can drive tumor evolution and the emergence of clinically apparent neoplasms. Mechanisms of immune escape acquired by less immunogenic variants during this process, termed immunoediting, may contribute significantly to malignant progression. In ...
متن کاملA novel IgM–H-Ficolin complement pathway to attack allogenic cancer cells in vitro
The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection and apoptotic cell clearance by activating the complement lectin pathway or a primitive opsonophagocytosis. It r...
متن کاملProspects in Adoptive Cell Transfer Therapy for Cancer
It has been documented that immunosurveillance plays an important role in cancer development in both human and animals [1,2]. Cancer immunosurveillance is the function of immune system in recognizing and reacting against aberrant cancer cells in the body. Thus, the interactions between cancer cells and immune cells play a pivotal role in cancer development. In cancer patients, however, tumors g...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 55 شماره
صفحات -
تاریخ انتشار 1982